New photoremovable protecting group reported

Thursday, September 1, 2016 - 10:30am

In a recent manuscript published in Organic and Biomolecular Chemistry, Graduate student Mohsen Mahmoodi in collaboration with the Blank group describe a new coumarin-based protecting group (mBhc) that can be used for thiol caging;  in contrast to Bhc, mBhc does not lead to to the formation of photorearranged isomeric products.  In addition to a variety of peptide-based experiments, they also demonstrated (in collaboration with the Soichet group at the University of Toronto) that this protecting group can be used to create 3D patterns in hydrogels using two-photon excitation.  These latter results open up a variety of new  biomaterials applications.

http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01045H#!divAbs...

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