Past Group Theses

Ph.D Theses

1.         Pfaff, J. L. Understanding the role of phytoplankton lipids in bioaccumulation. Ph.D., University of Minnesota, Minneapolis, 1996.

2.         Davies, R. R. The stereoselective hydrolysis of amino acid esters by protein-catalyst conjugates. Ph.D., University of Minnesota, Minneapolis, 1997.

3.         Edelstein, R. L. Enzymatic protein prenylation: photoaffinity labeling and mechanistic studies of protein prenyltransferases. Ph.D., University of Minnesota, Minneapolis, 1997.

4.         Turek, T. C. Enzymology of protein prenyltransferases: structural studies using photoaffinity labeling. Ph.D., University of Minnesota, Minneapolis, 1999.

5.         Weller, V. A. The enzymology of protein prenyltransferases: investigation of mechanism and inhibition. Ph.D., University of Minnesota, Minneapolis, 1999.

6.         Kale, T. A. Photoactivatable prenylated cysteine analogs: synthesis and applications in studies of prenylated proteins. Ph.D., University of Minnesota, Minneapolis, 2001.

7.         Kuang, H. Rational design of protein-based catalysts. Ph.D., University of Minnesota, Minneapolis, 2001.

8.         Jalas, J. R. Stereo- and regioselectivity in the cytochrome P450-mediated metabolism of the tobacco-specific nitrosamine 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Ph.D., University of Minnesota, Minneapolis, 2003.

9.         Qi, D. Rational design of artificial transaminases by chemical and genetic approaches. Ph.D., University of Minnesota, Minneapolis, 2003.

10.       Tann, C.-M. Design of artificial enzymes by site directed mutagenesis and chemical engineering of a protein cavity. Ph.D., University of Minnesota, Minneapolis, 2003.

11.       Duckworth, B. P. Site selective modification of proteins using protein farnesyltransferase. Ph.D., University of Minnesota, Minneapolis, 2007.

12.       Wollack, J. Multifunctional prenylated peptides for in vivo analysis. Ph.D., University of Minnesota, Minneapolis, 2009.

13.       DeGraw, A. Applications of Substrate Analogues for Studies of Prenyltransferase Enzymes. Ph.D., University of Minnesota, Minneapolis, 2010.

14.       Lenevich, S. Transition State Analysis of Protein Farnesyltransferase. Ph.D., University of Minnesota, Minneapolis, 2010.

15.       Leggans, E. K. Design and Synthesis of Polyketide-Based Labels for Polyketide Synthase Thioesterase and Ketoreductase Domains. Ph. D. University of Minnesota, Minneapolis, 2010.

16.       Abate-Pella, D. Synthesis and applications of caged thiols for studying protein prenylation. Ph.D. University of Minnesota, Minneapolis, 2011.

17.       Kyro, K. Photoaffinity labeling and characterization of protein targets using prenylated benzophenone-containing peptides. Ph.D., University of Minnesota, Minneapolis, 2011.

18.       Ochocki, J. D. Studies of protein prenylation in living systems: toward the better understanding of diseases. Ph.D., University of Minnesota, Minneapolis, 2012.

19.       Rashidian, M. Site specific protein labeling using farnesyl transferase. Ph.D., University of Minnesota, Minneapolis, 2013.

20.       Dozier, Jonathan K., Studies and Applications of Protein Prenylation Using Isoprenoid Analogues and Site-Directed Mutagenesis, Ph.D., University of Minnesota, Minneapolis, 2014.

21.       Wang, Yen-Chih, Solid-Phase Synthesis of C-Terminal Peptide Libraries for Studying the Specificity of Protein Farnesyltransferase, Ph.D., University of Minnesota, Minneapolis, 2014.

22.       Palsuledesai, C. Analysis of the penylated proteome in living systems: connecting the dots between diseases and therapeutics. Ph.D. 2015, University of Minnesota, Minneapolis, 2014.

23.       Diaz-Rodriguez, V. Solid phase synthesis of prenylated peptides containing C-terminal esters: a chemical biology tool for the study of protein prenylation. Ph.D. 2015

24.       Vervacke, J. Small molecules and functionalized peptides to study protein prenylation. Ph.D., University of Minnesota, Minneapolis, 2016

25.       Mahmoodi, Mohsen. Design and Synthesis of Caged Thiols for Development of Photo-Activatable Peptides, Inhibitors and Biomaterials, Ph.D., University of Minnesota, Minneapolis, 2016

26.       Krautkramer, E., Synthesis of Peptide-Based Small Molecule Probes to study Redox Status and Protein Prenylation, Ph.D., University of Minnesota Minneapolis, 2017

27.       Zhang, Y., Applications of Enzymatic Protein Labeling by Farnesyltransferase Towards Dual Protein Modification and Construction of Targeted Delivery Systems, Ph.D., University of Minnesota, Minneapolis, 2018

28.       Suazo, Kiall, Applications of chemical proteomics in defining prenylated proteomes and discovering novel prenylated proteins, Ph.D., University of Minnesota, Minneapolis, 2021

29        Park, Keun-Young, Enzymatic protein labeling and polymeric materials for cancer therapy and anti-fouling applications, Ph.D., University of Minnesota, Minneapolis, 2021

30.       Wang, Yiao, Prenylated Chemically Self-Assembled Nanorings: A Versatile Platform for Macro-Chemical Biology, Ph.D., University of Minnesota, Minneapolis, 2022

31.       Bader, Taysir, New Developments in Solid Phase Peptide Chemistry Facilitate the Study of of the Unique Metalloprotease  Ste24, Ph.D., University of Minnesota, Minneapolis, 2023

32.       Schey, Garrett, Evaluating and Exploiting the Substrate Selectivity of Farnesyltransferase, Ph.D., University of Minnesota, Minneapolis, 2023

 

M.S. Theses

1.         Rose, M. W. Attachment of azide containing isoprenoids onto a pentapeptide: a method for specifically labeling proteins via a modified Staudinger ligation. M.S., University of Minnesota, Minneapolis, 2002.

2.         Hsieh, S.-A. J. Studies directed towards the determination of the kinetic isotope effect of protein farnesyl transferase using mass spectrometry. M.S., University of Minnesota, Minneapolis, 2002.

3.         Albers, L. N. Kinetic isotope studies towards a transition state structure for the reaction catalyzed by protein farnesyltransferase. M.S. University of Minnesota, Minneapolis, 2005.

4.         Johnson, P. W. Investigation of Green Chemistry Experiments for the Organic Teaching Laboratory, Chem. 2311. M.S., University of Minnesota, Minneapolis, 2005.

5.         Hosokawa, A. Kinetic studies of alkyne-containing analogues of GPP and FPP using a continuous fluorescence assay and mechanistic studies of protein farnesyl transferase. M.S., University of Minnesota, Minneapolis, 2006.

6.         Novitske, A. Chemical warfare compendium. M.S., University of Minnesota, Minneapolis, 2006.

7.         Zhang, Z. E. Synthesis and applications of alkyne-containing substrates of protein farnesyltransferase for chemoenzymatic immobilization of proteins. M.S., University of Minnesota, Minneapolis, 2006.

 

B.S. Theses

1.         Singh, S. K. Purification and preliminary characterization of yeast ras farnesyl transferase. B.S. Summa Cum Laude, University of Minnesota, Minneapolis, 1995.

2.         Mathews, B. K. Preparation and evaluation of isoprenoid diphosphate analogs that incorporate azide functional groups: tools for understanding the anticancer properties of farnesyltransferase inhibitors. B.S. Summa Cum Laude, University of Minnesota, Minneapolis, 2004.

3.         Pierson, S. Oxidative catalysts based on leucine zipper templates. B.S. Cum Laude, University of Minnesota, Minneapolis, 2005.